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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
THOC2
All Species:
22.73
Human Site:
S74
Identified Species:
38.46
UniProt:
Q8NI27
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8NI27
NP_001075019.1
1593
182775
S74
S
N
V
L
S
D
I
S
E
F
R
E
D
M
P
Chimpanzee
Pan troglodytes
XP_001139291
1595
183045
S74
S
N
V
L
S
D
I
S
E
F
R
E
D
M
P
Rhesus Macaque
Macaca mulatta
XP_001086217
1593
182783
S74
S
N
V
L
N
D
I
S
E
F
R
E
D
M
P
Dog
Lupus familis
XP_538164
1593
182721
S74
S
N
V
L
N
D
I
S
E
F
R
E
D
M
P
Cat
Felis silvestris
Mouse
Mus musculus
B1AZI6
1594
182755
S74
S
S
V
L
N
D
I
S
E
F
R
E
D
M
P
Rat
Rattus norvegicus
XP_233081
1594
182711
S74
S
S
V
L
N
D
I
S
E
F
R
E
D
M
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510761
1648
188085
I125
S
N
V
L
N
D
I
I
E
F
R
D
D
M
P
Chicken
Gallus gallus
XP_420332
1593
182430
I71
S
G
V
L
A
D
I
I
E
F
R
E
D
M
P
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001003847
1504
172218
M71
A
S
L
L
A
D
V
M
E
L
R
D
D
M
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_722763
1641
188490
A133
H
L
L
L
E
V
V
A
L
H
A
D
F
P
S
Honey Bee
Apis mellifera
XP_393587
1354
156054
E32
L
I
K
H
K
F
K
E
G
N
T
A
E
W
R
Nematode Worm
Caenorhab. elegans
NP_498392
1437
164369
K63
A
D
N
A
S
T
S
K
E
N
F
E
S
F
V
Sea Urchin
Strong. purpuratus
XP_795489
1592
178912
V75
V
S
T
L
S
A
S
V
D
I
H
P
G
V
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_173871
1804
205705
P68
G
V
E
F
L
D
K
P
S
R
E
E
L
A
S
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99
99.9
99
N.A.
97.4
97.4
N.A.
85.8
88.1
N.A.
72.9
N.A.
39.7
43.1
29.5
48.7
Protein Similarity:
100
99.3
100
99.3
N.A.
98.9
99
N.A.
91.4
93.9
N.A.
83.4
N.A.
59
60.2
48.5
65.1
P-Site Identity:
100
100
93.3
93.3
N.A.
86.6
86.6
N.A.
80
80
N.A.
46.6
N.A.
6.6
0
20
13.3
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
93.3
86.6
N.A.
86.6
N.A.
33.3
6.6
33.3
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
31.1
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
48.4
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
15
0
0
8
15
8
0
8
0
0
8
8
0
8
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
8
0
0
0
72
0
0
8
0
0
22
65
0
0
% D
% Glu:
0
0
8
0
8
0
0
8
72
0
8
65
8
0
0
% E
% Phe:
0
0
0
8
0
8
0
0
0
58
8
0
8
8
0
% F
% Gly:
8
8
0
0
0
0
0
0
8
0
0
0
8
0
0
% G
% His:
8
0
0
8
0
0
0
0
0
8
8
0
0
0
0
% H
% Ile:
0
8
0
0
0
0
58
15
0
8
0
0
0
0
0
% I
% Lys:
0
0
8
0
8
0
15
8
0
0
0
0
0
0
0
% K
% Leu:
8
8
15
79
8
0
0
0
8
8
0
0
8
0
0
% L
% Met:
0
0
0
0
0
0
0
8
0
0
0
0
0
65
0
% M
% Asn:
0
36
8
0
36
0
0
0
0
15
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
8
0
0
0
8
0
8
65
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
8
65
0
0
0
8
% R
% Ser:
58
29
0
0
29
0
15
43
8
0
0
0
8
0
15
% S
% Thr:
0
0
8
0
0
8
0
0
0
0
8
0
0
0
0
% T
% Val:
8
8
58
0
0
8
15
8
0
0
0
0
0
8
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _